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Prof. Dr. Joachim Wittbrodt




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No, I jest blew away like old boots, While the driver, my mouth being busy, obligingly blew my cheroots. Tommy swore he was kidding me proper—we, Charlie! I like the idear. We have shown that the neuroretina is creating shape out of itself via a programmed behavior of neuroretinal stem cells. The pigmented epithelium on the other side arises from the same stem cell niche and passively follows the lead and shape implemented by the action of the neuroretinal stem cells. Our computational model for retinal growth is complemented by functional insights originating from clonal gain and loss of function analyses of key players governing the activity of retinal stem and progenitor cells.

We have employed stochastic activation of transcriptional modules that couple in vivo indicators with the gain or loss of function of key pathway components e. Those are of high interest since they appear to facilitate life-long growth of the retina in teleosts and their targeted inactivation has furthered our understanding of vertebrate retinal size control. Another striking feature of teleost eyes retinae is their apparently unlimited regenerative capacity. We will take advantage of the population genomics resource and establish further high throughput phenotyping pipelines to quantify regenerative and stem cell related phenotypes.

One particular focus will be on the interplay between stem cells and the immune system, an unexpected and tight interconnection that we recently uncovered. Another novel aspect of our work in the present years related to the medaka heart and the contribution of genetic and environmental factors to heart function at post-embryonic stages. GWAS on heart phenotypes is most advanced and we will use the heart as model for validating the relative contribution of individual SNPs to the heart phenotypes. We will first take advantage of newly established tools to map regulatory elements from human to medaka, in particular now incorporating the information provided by the sequenced genome of bridging species like the spotted gar.

Heidelberg Bibflirt uni

Taken together our approaches will be directed towards nui allow addressing the relative contribution of multiple factors and will heidslberg a first step towards addressing the genetics of individuality in different environmental contexts. We will take advantage of the population genomics resource and establish further high throughput phenotyping pipelines to quantify regenerative and stem cell related phenotypes. One particular focus will be on the interplay between stem cells and the immune system, an unexpected and tight interconnection that we recently uncovered. Another novel aspect of our work in the present years related to the medaka heart and the contribution of genetic and environmental factors to heart function at post-embryonic stages.

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GWAS on heart phenotypes is most advanced and we will use the heart as model for validating the relative contribution of individual SNPs to the heart phenotypes. We will first take advantage of newly established tools to map regulatory elements from human to medaka, in particular now incorporating the information provided by the sequenced genome of bridging species like the spotted gar. Taken together our approaches will be directed towards ultimately allow addressing the relative contribution of multiple factors and will be a first step towards addressing the genetics of individuality in different environmental contexts.

Vertebrate eye and brain development and regeneration The vertebrate eye is composed of neuroectodermal optic cup and surface ectodermal lens, cornea derivatives and it emerges from an epithelial Anlage by inductive interactions beginning al late gastrula stages. Under the influence of midline signaling during neurulation the single retina Anlage is split into two retinal primordia localized in the lateral wall of the forebrain.

Subsequent evagination of the primordia results in the formation of optic vesicles that differentiate to the seven unl types of the neural retina, the retinal pigmented epithelium and the optic stalk heiddelberg. In anamniotes fish, amphibiathe ciliary marginal zone CMZ of the neural retina contains a stem cell population that gives rise to all retinal cell types and facilitates life-long growth of the eye. The lab is studying neuronal cell proliferation and differentiation in the developing, growing and regenerating eye and brain of fish zebrafish, medaka as model system. We are combining genetic, molecular and cell biological approaches with advanced imaging approaches to decipher the basic mechanisms that govern the balance of cell proliferation and differentiation in vivo.


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